A after-test was answered by the pupils after the presentation of the lesson, having been the same test with the same questions, with the objective to evaluate with exactness the success of the proposal of intervention pointed for the academic necessity of this school. After all the theoretical process of learning and I practise, was opened the questions, that had been varied possible, that after answered, another one equal questionnaire to the first one was applied successfully, therefore the pupils had answered all the questions correctly, confirming the absorption of the content on the part of the pupils, since in the first questionnaire the answers pointed the existence of problems in the assimilation and interpretation of the pupils. Daily pay-test A questionnaire I contend 04 (four) questions on the material used in the laboratory lesson, of easy agreement and understanding, on cell and structure of the onion, was delivers to the pupils after to know the laboratory, place this who many at least knew, had answered the knowledge in accordance with that they would get. Graph 01: Questionnaire applied to the all the pupils previous to the intervention project Source: research carried through in a municipal public school in the city of Una/MG, December of 2010. In question 01 (one) it was asked of clear form what it was cellular wall, 90% of the pupils had answered that it was cytoplasm, being that the correct one would be the letter, Cell or cellular wall. Question 2 (two) varied a little of opinion, inside of the question on the constitution of the onion, the pupils had thought with total unfamiliarity on what they were answering, following to answer the questionnaire for insistence of the part of the palestrante therefore alleged not to have studied on this subject, asks this that would be the same one of the first one modifying only the formularization But in question 04 (four) the great majority correctly answered the question without not even knowing, factor this proven later, to the open being the questions, this was the first question made for them and if extending to all the same doubt.
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A subclass who must be cited is of the 2-cloroetil-metanossulfonatos. (2-cloroetil-sulfonil)? metil metanossulfonato (clomesona), although to present lesser activity cytotoxic that of the Bussulfan and the same types, one has revealed more selective in relation to the DNA, when compared with nitrossurias (Tong and Lundlum, 1980) .3.6. Antineoplsicos complexes of coordination of platinOs formed by composites of coordination with platinum, as the cisplatina (cis-DDP, commercially Platinil or Platinol) and the carboplatina (CBDCA, Paraplatin), alquilam the DNA (Najjar, 1992). The platinum complex suffers reaction from substitution of ligantes in the organism. For this, it must have in its structure a called group deserter, who must present moderate labilidade, being the chloride (CL) more widely used. Complexes with ligantes strong coordinate, as IN the 2 and SCN are inactive. An exception to this last generalization is the complexes contends ligantes double-toothed dicarboxilatos, that show activity and, due to its lesser reactivity, causes little collateral effect (Hahn and Weinberg, 2002).
Already complex with very lbeis ligantes, as the nitrate (IN the 3-), is very toxic and they do not show antitumoral activity. The ligantes that remain in the sphere of coordination of platinum, that is, those that they are not substituted in the organism must be relatively inert groups, as the amino ones. These double-toothed ligantes can be mono or. The double-toothed ones form preferential, with platinum, rings that are energetically favorable, as of five or six members. These ligantes follow the platinum atom until its target in the interior of the cell, and thus they shape the citotoxidez and the antitumoral effect of the complexes (Hahn and Weinberg, 2002). The carboplatina basically the same presents aspect of activity of the cisplatina, however with reduced collateral effect. Unhappyly, although better to be tolerated, the not active carboplatina in resistant cells to the cisplatina (Oliveira and Alves, 2002). Beyond the monometallic complexes, one another sufficiently promising platinum composite classroom is that one where the complexes present two on units of platinum for a diamina of changeable length of carbonic chain.